Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion systemArticle Published on 2022-10-012022-11-15 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] administration Analysis antibody Antigen antigens attenuated Salmonella ΔhtrA-VNP Bacterial caused CD44 CD69 COVID-19 vaccine cytometric cytosol delivery effective element elicited Express expression Flow fluorescence microscopy Heterologous IgA IgG in vitro increase in Macrophage mixed bacterial preparations. mutant N-protein NTD Oral vaccine pathogenicity phenotype Plasmid promoter RBD S-protein Safe Salmonella SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine screened secrete secretion shown Significance Significant significant increase SPI-2 strain T-cell activation T3SS the vaccine type III Vaccine was used [DOI] 10.1111/jam.15720 PMC 바로가기
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 spike protein. secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
[Abnormal expression of CD44 aggravates liver disease progression in patients with non-alcoholic fatty liver disease accompanied with hepatitis B virus replication]Article Published on 2021-11-202023-06-13 Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese [Category] B형 간염, [키워드] CD44 Chronic Liver Diseases Model Non-alcoholic fatty liver disease T lymphocyte. [DOI] 10.3760/cma.j.cn501113-20210713-00338 PMC 바로가기
Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infectionResearch Article Published on 2021-09-132022-10-28 Journal: Virulence [Category] Coronavirus, [키워드] activated activating antimicrobial peptide antiviral activity antiviral cytokine CD44 clinical Cluster cluster of differentiation 44 differentially expressed gene dysfunction ECM enterocytes epidemic diarrhea exhibited expression Extracellular Extracellular matrix Genes high mortality rate IL-11 IL-18 Infection Interaction intestinal intestinal epithelial cell intestinal tissue intestine investigated lesions mechanism network analysis nuclear Pathways PEDV Porcine epidemic diarrhea virus positive correlation potential therapeutic target progeny virion promote Replication resulting role serpin family E member 1 SERPINE1 Signaling significantly structural framework transcriptional level viral infection Viral load viral release viral replication virus virus infection [DOI] 10.1080/21505594.2021.1972202 PMC 바로가기 [Article Type] Research Article
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunctionCOVID-19는 내피 장벽 기능 장애를 직접 유도하는 히알루로난 단편을 생성합니다Research Article Published on 2021-09-082022-09-12 Journal: JCI Insight [Category] 진단, [키워드] activity analyzed CD44 circulating circulation Clinical severity Complication contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critical illness damaged Degradation degrade disease dysfunction dysregulated endothelial Endothelial cell enzyme Enzymes Evidence exacerbating Extracellular matrix functions generate glycobiology glycocalyx glycosaminoglycan Hyaluronan hyaluronidase induce Inflammatory cytokine Injury moderate moderate to severe morbidity Organ failure pathologic pathology patients with COVID-19 plasma Protective provide pulmonary regulate released Sepsis Severity of disease significantly Vascular Vascular Biology Vascular injury [DOI] 10.1172/jci.insight.147472 PMC 바로가기 [Article Type] Research Article
Hyaluronan and Its Receptors: Key Mediators of Immune Cell Entry and Trafficking in the Lymphatic SystemReview Published on 2021-08-122023-08-30 Journal: Cells [Category] E형 간염, [키워드] CD44 dendritic cell glycocalyx Hyaluronan Immune cell lymphatic endothelium LYVE-1 Macrophage T cell Trafficking [DOI] 10.3390/cells10082061 PMC 바로가기 [Article Type] Review
IL-13 is a driver of COVID-19 severityIL-13은 COVID-19 심각성의 동인입니다Research Article Published on 2021-08-092022-09-10 Journal: JCI Insight [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulation addition administration block blockade CD44 characteristic contribute COVID-19 COVID-19 severity cytokine Cytokines death disease severity downregulated gene Dupilumab dysregulation elevated Has1 highlighting Hyaluronan IL-13 IL-4 immune dysregulation immune system immunology implication independent Innate immunity less lung Lung disease Lungs mAb mechanical ventilation mechanism mediator mice Mortality mouse model neutralization open pathogenic Patient patient cohorts patients with COVID-19 plasma polysaccharide prevented pulmonary diseases Pulmonary pathology receptor reduced SARS-COV-2 infection SARS-CoV-2–infected mice severe COVID-19 severe disease Signaling Stage Th2 response the disease therapy Treatment understanding Viral Viral load was increased without affecting [DOI] 10.1172/jci.insight.150107 PMC 바로가기 [Article Type] Research Article
Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapyResearch Article Published on 2021-06-282022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] antibody antibody production Autoimmune disease B cells benefit blockade Cancer immunotherapy cancers CD4 CD44 CD8 Combination COVID-19 patient decrease Deleterious dose effectors examined expression HCQ Hydroxychloroquine Immune checkpoint blockade Immunotherapy increase in indicate infiltrating inhibited mice myeloid cells no effect patients PD-L1 promote Regulatory T cell rejection rheumatoid arthritis subset systemic lupus erythematosus T cell T cells Therapeutic benefit thymic treat Treatment Tregs tumor cells tumors vasculature [DOI] 10.1371/journal.pone.0251731 PMC 바로가기 [Article Type] Research Article
A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients특정 저밀도 호중구 개체군은 입원한 COVID-19 환자의 과응고 및 질병 중증도와 상관관계가 있습니다Research Article Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 바이오마커, [키워드] activated acute respiratory distress acute respiratory distress syndrome ARDS Asymptomatic Bronchoalveolar lavage fluid cause CD16 CD38 CD44 Cell changed circulating circulation clinical disease Coagulation Coagulopathy contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Critical disease CXCR3 cytokine cytokine production D-dimer demonstrated develop disease severity disease status exhibiting expressing expression ferritin Frequency hospitalized COVID-19 patient IL-6 Immune cell immune cells immunology Inflammatory life-threatening low-density marker Mild MONITOR neutrophil Neutrophil extracellular traps Neutrophils Patient patients with COVID-19 phagocytic capacity Platelets Pneumonia Prognosis progression proinflammatory gene respiratory respiratory distress SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 severe COVID-19 subset Symptoms syndrome systemic inflammation These cells TNF-α upper respiratory tract venous Viral viral pathogen Viral pneumonia with COVID-19 [DOI] 10.1172/jci.insight.148435 PMC 바로가기 [Article Type] Research Article